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Tracking and protection of transplanted stem cells using a ferrocenecarboxylic acid-conjugated peptide that mimics hTERT

Title
Tracking and protection of transplanted stem cells using a ferrocenecarboxylic acid-conjugated peptide that mimics hTERT
Author
고성호
Keywords
Neural stem cells; Mesenchymal stem cells; Tracking; MRI; Peptide; hTERT
Issue Date
2018-02
Publisher
ELSEVIER SCI LTD
Citation
BIOMATERIALS, v. 155, page. 80-91
Abstract
In vivo tracking of transplanted stem cells has been a central aim of stem cell therapy. Although many tracking systems have been introduced, no method has yet been validated for clinical applications. We developed a novel sophisticated peptide (GV1001) that mimics hTERT (human telomerase reverse transcriptase) and analysed its ability to track and protect stem cells after transplantation. Ferrocenecarboxylic acid-conjugated GV1001 (Fe-GV1001) efficiently penetrated stem cells with no adverse effects. Moreover, Fe-GV1001 improved the viability, proliferation; and migration of stem cells under hypoxia. After Fe-GV1001-labelled stem cells were transplanted into the brains of rats after stroke, the labelled cells were easily tracked by MRI. Our findings indicate that Fe-GV1001 can be used for the in vivo tracking of stem cells after transplantation into the brain and can improve the efficacy of stem cell therapy by sustaining and enhancing stem cell characteristics under disease conditions.
URI
https://www.sciencedirect.com/science/article/pii/S0142961217307408?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/117638
ISSN
0142-9612; 1878-5905
DOI
10.1016/j.biomaterials.2017.11.009
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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