17 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author채영규-
dc.date.accessioned2019-12-05T14:11:24Z-
dc.date.available2019-12-05T14:11:24Z-
dc.date.issued2018-02-
dc.identifier.citationTOXICOLOGY IN VITRO, v. 46, page. 66-76en_US
dc.identifier.issn0887-2333-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0887233317302862?via%3Dihub-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/117565-
dc.description.abstractDuring the differentiation process, various epigenetic factors regulate the precise expression of important genes and control cellular fate. During this stage, the differentiating cells become vulnerable to external stimuli. Here, we used an early neural differentiation model to observe ethanol-mediated transcriptional alterations. Our objective was to identify important molecular regulators of ethanol-related alterations in the genome during differentiation. A transcriptomic analysis was performed to profile the mRNA expression in differentiating embryoid bodies with or without ethanol treatment. In total, 147 differentially expressed genes were identified in response to 50 mM ethanol. Of these differentially expressed genes, 78 genes were up-regulated and 69 genes were down-regulated. Our analysis revealed a strong association among the transcript signatures of the important modulators which were involved in protein modification, protein synthesis and gene expression. Additionally, ethanol-mediated activation of DNA transcription was observed. We also profiled ethanol-responsive transcription factors (TFs), upstream transcriptional regulators and TF-binding motifs in the differentiating embryoid bodies. In this study, we established a platform that we hope will help other researchers determine the ethanol-mediated changes that occur during cellular differentiation.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP 2011-0030049).en_US
dc.language.isoen_USen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.subjectEthanolen_US
dc.subjectNeural differentiationen_US
dc.subjectGene expressionen_US
dc.subjectTranscription factorsen_US
dc.subjectDNA transcriptionen_US
dc.subjectPost-translational modificationen_US
dc.titleGene expression signatures after ethanol exposure in differentiating embryoid bodiesen_US
dc.typeArticleen_US
dc.relation.volume46-
dc.identifier.doi10.1016/j.tiv.2017.10.004-
dc.relation.page66-76-
dc.relation.journalTOXICOLOGY IN VITRO-
dc.contributor.googleauthorMandal, Chanchal-
dc.contributor.googleauthorKim, Sun Hwa-
dc.contributor.googleauthorChai, Jin Choul-
dc.contributor.googleauthorLee, Young Seek-
dc.contributor.googleauthorJung, Kyoung Hwa-
dc.contributor.googleauthorChai, Young Gyu-
dc.relation.code2018002363-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidygchai-
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE