Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양철수 | - |
dc.date.accessioned | 2019-12-04T05:59:13Z | - |
dc.date.available | 2019-12-04T05:59:13Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | AUTOPHAGY, v. 14, no. 1, page. 152-168 | en_US |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.issn | 1554-8635 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/15548627.2017.1339001 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/117247 | - |
dc.description.abstract | The orphan nuclear receptor ESRRA (estrogen-related receptor alpha) is a key regulator of energy homeostasis and mitochondrial function. Macroautophagy/autophagy, an intracellular degradation process, is a critical innate effector against intracellular microbes. Here, we demonstrate that ESRRA is required for the activation of autophagy to promote innate antimicrobial defense against mycobacterial infection. AMP-activated protein kinase pathway and SIRT1 (sirtuin 1) activation led to induction of ESRRA, which is essential for autophagosome formation, in bone marrow-derived macrophages. ESRRA enhanced the transcriptional activation of numerous autophagy-related (Atg) genes containing ERR response elements in their promoter regions. Furthermore, ESRRA, operating in a feed-forward loop with SIRT1, was required for autophagy activation through deacetylation of ATG5, BECN1, and ATG7. Importantly, ESRRA deficiency resulted in a decrease of phagosomal maturation and antimicrobial responses against mycobacterial infection. Thus, we identify ESRRA as a critical activator of autophagy via both transcriptional and post-translational control to promote antimicrobial host responses. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2015M3C9A2054326 and 2017R1A5A2015385) at Chungnam National University and No. NRF-2016R1D1A1A02937312 at Hanyang University, by a grant of the Korea Healthcare Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant HI15C0395 and HI16C1653). This work was supported by National Creative Research Initiatives Grant (20110018305) through the National Research Foundation of Korea (NRF) funded by the Korean government (Ministry of Science, ICT & Future Planning) to HSC. This work was supported under the framework of international cooperation program managed by National Research Foundation of Korea 2015K2A2A6002008. This work was funded by the Canadian Institutes of Health Research (MOP-125885) to VG. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | TAYLOR & FRANCIS INC | en_US |
dc.subject | autophagy-related genes | en_US |
dc.subject | estrogen-related receptor alpha | en_US |
dc.subject | innate antimicrobial defense | en_US |
dc.subject | Mycobacterium tuberculosis | en_US |
dc.subject | post-translational modifications | en_US |
dc.subject | sirtuin 1 | en_US |
dc.title | ESRRA (estrogen-related receptor alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 14 | - |
dc.identifier.doi | 10.1080/15548627.2017.1339001 | - |
dc.relation.page | 152-168 | - |
dc.relation.journal | AUTOPHAGY | - |
dc.contributor.googleauthor | Kim, Soo Yeon | - |
dc.contributor.googleauthor | Yang, Chul-Su | - |
dc.contributor.googleauthor | Lee, Hye-Mi | - |
dc.contributor.googleauthor | Kim, Jin Kyung | - |
dc.contributor.googleauthor | Kim, Yi-Sak | - |
dc.contributor.googleauthor | Kim, Ye-Ram | - |
dc.contributor.googleauthor | Kim, Jae-Sung | - |
dc.contributor.googleauthor | Kim, Tae Sung | - |
dc.contributor.googleauthor | Yuk, Jae-Min | - |
dc.contributor.googleauthor | Dufour, Catherine Rosa | - |
dc.relation.code | 2018009182 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | chulsuyang | - |
dc.identifier.orcid | https://orcid.org/0000-0003-4918-961X | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.