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Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene

Title
Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene
Author
KUTZNER ARNE HOLGER
Keywords
brain; FAM72; learning; memory; neuron; p17; SRGAP2; synapse
Issue Date
2018-01
Publisher
WALTER DE GRUYTER GMBH
Citation
BIOLOGICAL CHEMISTRY, v. 399, no. 1, page. 55-61
Abstract
Due to an aging society with an increased dementia-induced threat to higher cognitive functions, it has become imperative to understand the molecular and cellular events controlling the memory and learning processes in the brain. Here, we suggest that the novel master gene pair |-SRGAP2-FAM72-| (SLIT-ROBO Rho GTPase activating the protein 2, family with sequence similarity to 72) reveals a new dogma for the regulation of neural stem cell (NSC) gene expression and is a distinctive player in the control of human brain plasticity. Insight into the specific regulation of the brain-specific neural master gene |-SRGAP2-FAM72-| may essentially contribute to novel therapeutic approaches to restore or improve higher cognitive functions.
URI
https://www.degruyter.com/view/j/bchm.2018.399.issue-1/hsz-2017-0190/hsz-2017-0190.xmlhttp://repository.hanyang.ac.kr/handle/20.500.11754/117229
ISSN
1431-6730; 1437-4315
DOI
10.1515/hsz-2017-0190
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > INFORMATION SYSTEMS(정보시스템학과) > Articles
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