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Colonic immune cells in irritable bowel syndrome: A systematic review and meta-analysis

Title
Colonic immune cells in irritable bowel syndrome: A systematic review and meta-analysis
Author
이오영
Keywords
colonic biopsies; immunity; irritable bowel syndrome; lymphocytes; mast cell
Issue Date
2018-01
Publisher
WILEY
Citation
NEUROGASTROENTEROLOGY AND MOTILITY, v. 30, no. 1, Article no. e13192
Abstract
Background & AimsIncreases in mucosal immune cells have frequently been observed in irritable bowel syndrome (IBS) patients. However, this finding is not completely consistent between studies, possibly due to a combination of methodological variability, population differences and small sample sizes. We performed a meta-analysis of case-control studies that compared immune cell counts in colonic biopsies of IBS patients and controls.MethodsPubMed and Embase were searched in February 2017. Results were pooled using standardized mean difference (SMD) and were considered significant when zero was not within the 95% confidence interval (CI). Heterogeneity was assessed based on I-2 statistics where I(2)50% and I-2>50% indicated fixed and random effect models, respectively.Key ResultsTwenty-two studies on 706 IBS patients and 401 controls were included. Mast cells were increased in the rectosigmoid (SMD: 0.38 [95% CI: 0.06-0.71]; P=.02) and descending colon (SMD: 1.69 [95% CI: 0.65-2.73]; P=.001) of IBS patients. Increased mast cells were observed in both constipation (IBS-C) and diarrhea predominant IBS (IBS-D). CD3(+) T cells were increased in the rectosigmoid (SMD: 0.53 [95% CI: 0.21-0.85]; P=.001) and the descending colon of the IBS patients (SMD: 0.79, 95% CI [0.28-1.30]; P=.002). This was possibly in relation to higher CD4(+) T cells in IBS (SMD: 0.33 [95% CI: 0.01-0.65]; P=.04) as there were no differences in CD8(+) T cells.Conclusions & InferencesMast cells and CD3(+) T cells are increased in colonic biopsies of patients with IBS vs non-inflamed controls. These changes are segmental and sometimes IBS-subtype dependent. The diagnostic value of the quantification of colonic mucosal cells in IBS requires further investigation.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1111/nmo.13192https://repository.hanyang.ac.kr/handle/20.500.11754/117189
ISSN
1350-1925; 1365-2982
DOI
10.1111/nmo.13192
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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