9 0

Metal-Free One-Pot Synthesis of (Tetrahydro)Quinolines through Three-Component Assembly of Arenediazonium Salts, Nitriles, and Styrenes

Title
Metal-Free One-Pot Synthesis of (Tetrahydro)Quinolines through Three-Component Assembly of Arenediazonium Salts, Nitriles, and Styrenes
Author
윤소원
Keywords
multicomponent reactions; nitrogen heterocycles; one-pot reaction; quinolines; tetrahydroquinolines
Issue Date
2018-01
Publisher
WILEY-V C H VERLAG GMBH
Citation
ADVANCED SYNTHESIS & CATALYSIS, v. 360, no. 2, page. 278-283
Abstract
A highly efficient and convenient metal-free, one-pot synthesis of diversely substituted (tetrahydro)quinolines has been achieved through a three-component assembly reaction of arenediazonium salts, nitriles, and styrenes. In sharp contrast to the prior works with the same reagent blend, the formation of N-arylnitrilium intermediates from arenediazonium salts and nitriles was followed by reaction with styrenes, leading to 3,4-dihydroquinolinium salts as a common intermediate. These could be further transformed to quinolines and tetrahydroquinolines depending on the reaction conditions. The advantages of this protocol include its simplicity, metal-free and mild conditions, readily available starting materials, and good functional group tolerance.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.201701451http://repository.hanyang.ac.kr/handle/20.500.11754/117028
ISSN
1615-4150; 1615-4169
DOI
10.1002/adsc.201701451
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE