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Does formaldehyde have a causal association with nasopharyngeal cancer and leukaemia?

Title
Does formaldehyde have a causal association with nasopharyngeal cancer and leukaemia?
Author
김인아
Keywords
Formaldehyde; Nasopharyngeal neoplasm; Leukemia; Workers' compensation; Occupational diseases
Issue Date
2018-01
Publisher
BIOMED CENTRAL LTD
Citation
ANNALS OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, v. 30, Article no. 5
Abstract
Background: The South Korean criteria for occupational diseases were amended in July 2013. These criteria included formaldehyde as a newly defined occupational carcinogen, based on cases of "leukemia or nasopharyngeal cancer caused by formaldehyde exposure". This inclusion was based on the Internal Agency for Research on Cancer classification, which classified formaldehyde as definite human carcinogen for nasopharyngeal cancer in 2004 and leukemia in 2012.Methods: We reviewed reports regarding the causal relationship between occupational exposure to formaldehyde in Korea and the development of these cancers, in order to determine whether these cases were work-related.Results: Previous reports regarding excess mortality from nasopharyngeal cancer caused by formaldehyde exposure seemed to be influenced by excess mortality from a single plant. The recent meta-risk for nasopharyngeal cancer was significantly increased in case-control studies, but was for cohort studies (excluding unexplained clusters of nasopharyngeal cancers). A recent analysis of the largest industrial cohort revealed elevated risks of both leukemia and Hodgkin lymphoma at the peak formaldehyde exposure, and both cancers exhibited significant dose-response relationships. A nested case-control study of embalmers revealed that mortality from myeloid leukemia increased significantly with increasing numbers of embalms and with increasing formaldehyde exposure. The recent meta-risks for all leukemia and myeloid leukemia increased significantly. In South Korea, a few cases were considered occupational cancers as a result of mixed exposures to various chemicals (e.g., benzene), although no cases were compensated for formaldehyde exposure. The peak formaldehyde exposure levels in Korea were 2.70-14.8 ppm in a small number of specialized studies, which considered anatomy students, endoscopy employees who handled biopsy specimens, and manufacturing workers who were exposed to high temperatures.Conclusion: Additional evidence is needed to confirm the relationship between formaldehyde exposure and nasopharyngeal cancer. All lymphohematopoietic malignancies, including leukemia, should be considered in cases with occupational formaldehyde exposure.
URI
https://aoemj.org/DOIx.php?id=10.1186/s40557-018-0218-zhttp://repository.hanyang.ac.kr/handle/20.500.11754/116928
ISSN
2052-4374
DOI
10.1186/s40557-018-0218-z
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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