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Characterization of Raman Scattering in Solid Samples with Different Particle Sizes and Elucidation on the Trends of Particle Size-Dependent Intensity Variations in Relation to Changes in the Sizes of Laser Illumination and Detection Area

Title
Characterization of Raman Scattering in Solid Samples with Different Particle Sizes and Elucidation on the Trends of Particle Size-Dependent Intensity Variations in Relation to Changes in the Sizes of Laser Illumination and Detection Area
Author
정회일
Keywords
PRINCIPAL-COMPONENTS-ANALYSIS; MONTE-CARLO SIMULATIONS; QUANTITATIVE-ANALYSIS; PHARMACEUTICAL TABLETS; POLYMORPHIC MIXTURES; PHOTON MIGRATION; SPECTROSCOPY; POWDERS; SIGNAL
Issue Date
2017-12
Publisher
AMER CHEMICAL SOC
Citation
ANALYTICAL CHEMISTRY, v. 89, no. 22, page. 11937-11943
Abstract
We have systematically characterized Raman scatterings in solid samples with different particle sizes and investigated subsequent trends of particle size-induced intensity variations. For this purpose, both lactose powders and pellets composed of five different particle sizes were prepared. Uniquely in this study, three spectral acquisition schemes with different sizes of laser illuminations and detection windows were employed for the evaluation, since it was expected that the experimental configuration would be another factor potentially influencing the intensity of the lactose peak, along with the particle size itself. In both samples, the distribution of Raman photons became broader with the increase in particle size, as the mean free path of laser photons, the average photon travel distance between consecutive scattering locations, became longer under this situation. When the particle size was the same, the Raman photon distribution was narrower in the pellets since the individual particles were more densely packed in a given volume (the shorter mean free path). When the size of the detection window was small, the number of photons reaching the detector decreased as the photon distribution was larger. Meanwhile, a large-window detector was able to collect the widely distributed Raman photons more effectively; therefore, the trends of intensity change with the variation in particle size were dissimilar depending on the employed spectral acquisition schemes. Overall, the Monte Carlo simulation was effective at probing the photon distribution inside the samples and helped to support the experimental observations.
URI
https://pubs.acs.org/doi/10.1021/acs.analchem.7b01400https://repository.hanyang.ac.kr/handle/20.500.11754/116688
ISSN
0003-2700; 1520-6882
DOI
10.1021/acs.analchem.7b01400
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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