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Gene delivery to pancreatic islets for effective transplantation in diabetic animal

Title
Gene delivery to pancreatic islets for effective transplantation in diabetic animal
Author
이민형
Keywords
Diabetes; Pancreatic islets transplantation; Gene delivery; Therapeutic genes
Issue Date
2017-12
Publisher
ELSEVIER SCIENCE INC
Citation
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 56, page. 45-54
Abstract
Pancreas islet transplantation is a promising approach to cure diabetes mellitus. However, transplanted islets are easily damaged by hypoxic microenvironment and immunosuppressive agents. Cytoprotective gene delivery into islets could overcome those challenges by expressing the transferred therapeutic genes. In this circumstance, several factors need to be considered for genetic modification of pancreas islets. First, safe and efficient gene delivery tools should be developed. Second, effective therapeutic genes with few side-effects should be developed. Furthermore, strong gene regulation and expression systems are required. Therefore, we here review various gene-carriers and therapeutic genes for genetic engineering of pancreatic islets ex vivo.
URI
https://www.sciencedirect.com/science/article/pii/S1226086X17304124?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/116605
ISSN
1226-086X; 1876-794X
DOI
10.1016/j.jiec.2017.07.038
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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