Directed Fischer Indolization as an Approach to the Total Syntheses of (+)-Aspidospermidine and (-)-Tabersonine
- Title
- Directed Fischer Indolization as an Approach to the Total Syntheses of (+)-Aspidospermidine and (-)-Tabersonine
- Author
- 조천규
- Keywords
- BIOMIMETIC ALKALOID SYNTHESES; ASPIDOSPERMA ALKALOIDS; ALLYLIC OXIDATION; PRIMARY ALCOHOLS; INDOLE SYNTHESIS; (+/-)-ASPIDOSPERMIDINE; (-)-ASPIDOSPERMIDINE; (-)-VINCADIFFORMINE; (+/-)-TABERSONINE; REARRANGEMENT
- Issue Date
- 2017-11
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v. 19, no. 22, page. 6168-6171
- Abstract
- A conceptually new synthetic approach that provides general access to the aspidosperma alkaloids (+)-aspidospermidine and (-)-tabersonine was developed. This method is based on the regioselective indolization of an ene-hydrazide, which was obtained via a base-catalyzed intramolecular aza-Michael reaction, in situ trapping of the resulting enolate, and subsequent C-N coupling with phenyl hydrazide.
- URI
- https://pubs.acs.org/doi/10.1021/acs.orglett.7b03078https://repository.hanyang.ac.kr/handle/20.500.11754/116217
- ISSN
- 1523-7060; 1523-7052
- DOI
- 10.1021/acs.orglett.7b03078
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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