Centiloid method evaluation for amyloid PET of subcortical vascular dementia
- Title
- Centiloid method evaluation for amyloid PET of subcortical vascular dementia
- Author
- 이종민
- Keywords
- WHITE-MATTER REFERENCE; VOXEL-BASED ANALYSIS; ALZHEIMERS-DISEASE; REFERENCE REGION; COMPOUND-B; BRAIN; DEPOSITION; MUTATION; PATHOLOGIES; DIAGNOSIS
- Issue Date
- 2017-11
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v. 7, Article no. 16322
- Abstract
- Reference region selection is important for proper amyloid PET analysis, especially in subcortical vascular dementia (SVaD) patients. We investigated reference region differences between SVaD and Alzheimer's disease (AD) using Centiloid scores. In 57 [C-11] Pittsburgh compound B (PiB) positive (+) AD and 23 PiB (+) SVaD patients, we assessed standardized PiB uptake and Centiloid scores in disease-specific cortical regions, with several reference regions: cerebellar gray (CG), whole cerebellum (WC), WC with brainstem (WC + B), pons, and white matter (WM). We calculated disease group differences from young controls (YC) and YC variance according to reference region. SVaD patients showed large effect sizes (Cohen's d>0.8) using all reference regions. WM and pons showed largerYC variances than other regions. Findings were similar for AD patients. CG, WC, and WC + B, but not WM or pons, are reliable reference regions for amyloid imaging analysis in SVaD.
- URI
- https://www.nature.com/articles/s41598-017-16236-1https://repository.hanyang.ac.kr/handle/20.500.11754/116131
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-017-16236-1
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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