Enhancement of T-2-weighted MR contrast using heparin for cell tracking in vivo
- Title
- Enhancement of T-2-weighted MR contrast using heparin for cell tracking in vivo
- Author
- 이동윤
- Keywords
- MRI; Superparamagnetic iron oxide (SPIO); Heparin; Cellular tracking; Cell transplantation
- Issue Date
- 2017-11
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 55, page. 183-190
- Abstract
- Superparamagnetic iron oxide (SPIO) nanoparticle has emerged as a novel probe for noninvasively cellular tracking using magnetic resonance imaging. Here we developed SPIO nanoparticles coated with biocompatible heparin, i.e., low-molecular-weight-heparin (LMWH) or unfractionated heparin (UFH). These heparin-SPIO nanoparticles showed good crystallizability and stability without self-aggregation for 50 days. Also, UFH-SPIO nanoparticle had lower relaxation time with higher relaxivity. Moreover, they were efficiently internalized into cells without cytotoxicity and had faster saturated magnetization. Furthermore, the implanted SPIO nanoparticles-labeled Ins-1 cells were strongly visualized in vivo MR imaging. Collectively, heparin-based SPIO nanoparticles could have a great potential for in vivo cellular tracking. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S1226086X17303325?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/116126
- ISSN
- 1226-086X; 1876-794X
- DOI
- 10.1016/j.jiec.2017.06.043
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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