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A simple and dual responsive ultrasensitive thioether-functionalized pyrenesulfonamide for the cascade detection of mercury ion and dithiouracil, a mimetic system for molecular logic gates

Title
A simple and dual responsive ultrasensitive thioether-functionalized pyrenesulfonamide for the cascade detection of mercury ion and dithiouracil, a mimetic system for molecular logic gates
Author
채필석
Keywords
Pyrene excimer emission; Hg2+ sensor; Dithiouracil detection; Dynamic quenching; Cascade detectiona
Issue Date
2017-11
Publisher
ELSEVIER SCIENCE SA
Citation
SENSORS AND ACTUATORS B-CHEMICAL, v. 251, page. 416-426
Abstract
A thioether-functionalized probe with a dipodal pyrene-sulfonamide fluorophore (probe 1) was synthesized for the selective and sensitive detection of Hg2+ in aqueous solutions. In addition, a probe with a monopod pyrene-sulfonamide unit was prepared (probe 2). Among various metal ions, these two probes appeared to selectively bind to Hg2+ at a 1: 1 ratio, with a stronger association of probe 1 than probe 2, as evidenced by titration experiments. The green emission displayed by probe 1 was completely quenched by the coordination of Hg2+ to sulfur (ON-OFF), presumably via energy transfer from the pyrene fluorophore to the [sulfur-Hg2+] unit. The limit of detection (LOD) was 1 nM (0.22 ppb), one of the lowestvalues obtained so far. Furthermore, the in situ-prepared [1+Hg2+] complex continued to be utilized to selectively detect dithiouracil (DTU) via an "OFF-ON" mechanism among diverse biomolecules, along with an LOD of 20 nM. Thus, probe 1 alone or together with Hg2+ allowed the cascade detection of Hg2+ and DTU with high selectivity and ultra-sensitivity. The current study indicates that probe 1 not only serves as an 'INHIBIT and AND' logic gate, but also works as an "ON-OFF-ON" molecular switch triggered by the sequential addition of Hg2+ and DTU. (C) 2017 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0925400517308973?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/116096
ISSN
0925-4005
DOI
10.1016/j.snb.2017.05.077
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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