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Quantitative evaluation of hard exudates in diabetic macular edema after short-term intravitreal triamcinolone, dexamethasone implant or bevacizumab injections

Title
Quantitative evaluation of hard exudates in diabetic macular edema after short-term intravitreal triamcinolone, dexamethasone implant or bevacizumab injections
Author
성민철
Keywords
Bevacizumab; Dexamethasone implant; Diabetic macular edema; Hard exudate; Triamcinolone
Issue Date
2017-10
Publisher
BMC
Citation
BMC OPHTHALMOLOGY, v. 17, Article no. 182
Abstract
Background: To quantitatively compare short-term hard exudates (HEs) alteration in patients with diabetic macular edema (DME) after intravitreal triamcinolone, dexamethasone implant or bevacizumab injections. Methods: This retrospective study enrolled DME eyes with HEs that underwent a single-dose intravitreal injection of triamcinolone (25 eyes), dexamethasone implant (20 eyes), or three monthly injections of bevacizumab (25 eyes) and completed at least three months of follow-up. All patients were examined before and after 1, 2 and 3 months of injections. Using color fundus photographs, the amount of HEs was quantified by two masked graders. The difference in HEs area between baseline and each follow-up visit was compared among the three groups. Results: After three months, HEs area was reduced to 52.9 +/- 4.21% (P < 0.001) in the triamcinolone group, 63.6 +/- 6. 08% (P = 0.002) in the dexamethasone implant group, and 85.2 +/- 5.07% (P = 0.198) in the bevacizumab group. A significant reduction in HEs appeared at one month in the triamcinolone group (53.5 +/- 4.91%, P < 0.001) and at two months in the dexamethasone implant group (70.1 +/- 5.21%, P = 0.039). Conclusions: Our study suggests intravitreal steroids (triamcinolone, dexamethasone implants) significantly reduce HEs in DME patients on short-term follow-up, whereas intravitreal bevacizumab does not. Therefore, intravitreal steroids may be useful in DME with HEs in the fovea.
URI
https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-017-0578-0http://repository.hanyang.ac.kr/handle/20.500.11754/115915
ISSN
1471-2415
DOI
10.1186/s12886-017-0578-0
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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