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Functional repertoire of interleukin-6 in the central nervous system - a review

Title
Functional repertoire of interleukin-6 in the central nervous system - a review
Author
Klaus Heese
Keywords
Brain; IL-6; neural stem cell; neurogenesis; neuron; signaling; synapse
Issue Date
2017-10
Publisher
IOS PRESS
Citation
RESTORATIVE NEUROLOGY AND NEUROSCIENCE, v. 35, no. 6, page. 693-701
Abstract
In an aging society with dementia imposing an increasing threat to higher brain cognitive functions, understanding the molecular and cellular events of adult neurogenesis is imperative. Interleukin-6 (IL-6), along with its agonistic acting soluble receptor sIL-6R (the combined proteins are also known as Hyper-IL-6), is a promising cytokine that can support neurogenesis under conditions of neurodegeneration when neuron replacement is needed. In contrast to the previously reported gliogenic effects of activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis, this review summarizes recent studies showing that IL-6 activation can be neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease.
URI
https://content.iospress.com/articles/restorative-neurology-and-neuroscience/rnn170772http://repository.hanyang.ac.kr/handle/20.500.11754/115896
ISSN
0922-6028; 1878-3627
DOI
10.3233/RNN-170772
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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