Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신인철 | - |
dc.date.accessioned | 2019-12-01T11:39:35Z | - |
dc.date.available | 2019-12-01T11:39:35Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.citation | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, v. 636, page. 110-122 | en_US |
dc.identifier.issn | 0003-9861 | - |
dc.identifier.issn | 1096-0384 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0003986117302631?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/115807 | - |
dc.description.abstract | Cancer cells require increased aerobic glycolysis to support rapid cell proliferation. For their increased energy demands, cancer cells express glucose transporter (Glut) proteins at a high level. Glut1 is associated with basal-like breast cancer and is considered a potential therapeutic target. To investigate the possibility of Glut1 as a therapeutic target in breast cancer cells, we downregulated Glut1 in triple negative breast cancer (TNBC) cell lines using a short hairpin system. We determined whether Glut1 silencing might enhance anti-proliferative effect of chemotherapeutic agents. Contrary to our hypothesis, ablation of Glut1 attenuated apoptosis and increased drug resistance via upregulation of p-Akt/p-GSK-3 beta (Ser9)/beta-cateninisurvivin. These results indicated that the potential of Glut1 as a therapeutic target should be carefully reevaluated. (C) 2017 Published by Elsevier Inc. | en_US |
dc.description.sponsorship | This work was supported by an NRF grant (2016R1A2B4011196) from the Korea Research Foundation. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.subject | Glut1 | en_US |
dc.subject | Chemoresistance | en_US |
dc.subject | Triple-negative breast cancer | en_US |
dc.title | Silencing of Glut1 induces chemoresistance via modulation of Akt/GSK-3 beta/beta-catenin/survivin signaling pathway in breast cancer cells | en_US |
dc.type | Article | en_US |
dc.relation.volume | 636 | - |
dc.identifier.doi | 10.1016/j.abb.2017.08.009 | - |
dc.relation.page | 110-122 | - |
dc.relation.journal | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | - |
dc.contributor.googleauthor | Oh, Sunhwa | - |
dc.contributor.googleauthor | Kim, Hyungjoo | - |
dc.contributor.googleauthor | Nam, KeeSoo | - |
dc.contributor.googleauthor | Shin, Incheol | - |
dc.relation.code | 2017003070 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | incheol | - |
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