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Silencing of Glut1 induces chemoresistance via modulation of Akt/GSK-3 beta/beta-catenin/survivin signaling pathway in breast cancer cells

Title
Silencing of Glut1 induces chemoresistance via modulation of Akt/GSK-3 beta/beta-catenin/survivin signaling pathway in breast cancer cells
Author
신인철
Keywords
Glut1; Chemoresistance; Triple-negative breast cancer
Issue Date
2017-10
Publisher
ELSEVIER SCIENCE INC
Citation
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, v. 636, page. 110-122
Abstract
Cancer cells require increased aerobic glycolysis to support rapid cell proliferation. For their increased energy demands, cancer cells express glucose transporter (Glut) proteins at a high level. Glut1 is associated with basal-like breast cancer and is considered a potential therapeutic target. To investigate the possibility of Glut1 as a therapeutic target in breast cancer cells, we downregulated Glut1 in triple negative breast cancer (TNBC) cell lines using a short hairpin system. We determined whether Glut1 silencing might enhance anti-proliferative effect of chemotherapeutic agents. Contrary to our hypothesis, ablation of Glut1 attenuated apoptosis and increased drug resistance via upregulation of p-Akt/p-GSK-3 beta (Ser9)/beta-cateninisurvivin. These results indicated that the potential of Glut1 as a therapeutic target should be carefully reevaluated. (C) 2017 Published by Elsevier Inc.
URI
https://www.sciencedirect.com/science/article/abs/pii/S0003986117302631?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/115807
ISSN
0003-9861; 1096-0384
DOI
10.1016/j.abb.2017.08.009
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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