Conformation-switchable helical polypeptide eliciting selective pro-apoptotic activity for cancer therapy
- Title
- Conformation-switchable helical polypeptide eliciting selective pro-apoptotic activity for cancer therapy
- Author
- 윤채옥
- Keywords
- pH-activated helical formation; Mitochondrial membrane destabilization; Pro-apoptotic activity; Cancer targeting and therapy
- Issue Date
- 2017-10
- Publisher
- ELSEVIER SCIENCE BV
- Citation
- JOURNAL OF CONTROLLED RELEASE, v. 264, page. 24-33
- Abstract
- Artificial cationic helical peptides possess an enhanced cell-penetrating property. However, their cell-penetrability is not converted by cellular environmental changes resulting in nonspecific uptake. In this study, pH-sensitive anion-donating groups were added to a helical polypeptide to simultaneously achieve tumor targeting and pro-apoptotic activity. The mitochondria-destabilizing helical polypeptide undergoing pH-dependent conformational transitions selectively targeted cancer cells consequently disrupting mitochondrial membranes and subsequently inducing apoptosis. This work presents a promising peptide therapeutic system for cancer therapy.
- URI
- https://www.sciencedirect.com/science/article/pii/S016836591730768X?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/115785
- ISSN
- 0168-3659; 1873-4995
- DOI
- 10.1016/j.jconrel.2017.08.001
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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