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Prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the United States

Title
Prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the United States
Author
전대원
Keywords
EXTERNAL VALIDATION; HEPATIC STEATOSIS; INDEX; DIAGNOSIS; ASSOCIATION; POPULATION; MARKERS; SCORE
Issue Date
2017-09
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v. 12, no. 3, Article no. e0173499
Abstract
In the United States, non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and associated with higher mortality according to data from earlier National Health and Nutrition Examination Survey (NHANES) 1988-1994. Our goal was to determine the NAFLD prevalence in the recent 1999-2012 NHANES, risk factors for advanced fibrosis (stage 3-4) and mortality. NAFLD was defined as having a United States Fatty Liver Index (USFLI) > 30 in the absence of heavy alcohol use and other known liver diseases. The probability of low/high risk of having advanced fibrosis was determined by the NAFLD Fibrosis Score (NFS). In total, 6000 persons were included; of which, 30.0% had NAFLD and 10.3% of these had advanced fibrosis. Five and eight-year overall mortality in NAFLD subjects with advanced fibrosis was significantly higher than subjects without NAFLD ((18% and 35% vs. 2.6% and 5.5%, respectively) but not NAFLD subjects without advanced fibrosis (1.1% and 2.8%, respectively). NAFLD with advanced fibrosis (but not those without) is an independent predictor for mortality on multivariate analysis (HR = 3.13, 95% CI 1.93-5.08, p<0.001). In conclusion, in this most recent NHANES, NAFLD prevalence remains at 30% with 10.3% of these having advanced fibrosis. NAFLD per se was not a risk factor for increased mortality, but NAFLD with advanced fibrosis was. Mexican American ethnicity was a significant risk factor for NAFLD but not for advanced fibrosis or increased mortality.
URI
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173499http://repository.hanyang.ac.kr/handle/20.500.11754/115676
ISSN
1932-6203
DOI
10.1371/journal.pone.0173499
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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