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ABCG2 Polymorphism Is Associated with Hyperuricemia in a Study of a Community-Based Korean Cohort

Title
ABCG2 Polymorphism Is Associated with Hyperuricemia in a Study of a Community-Based Korean Cohort
Author
성윤경
Keywords
ABCG2; Hyperuricemia; Uric Acid
Issue Date
2017-09
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v. 32, no. 9, page. 1451-1459
Abstract
The purpose of the present study was to find novel loci associated with hyperuricemia using data from a genome-wide association study (GWAS) conducted on healthy Koreans. We conducted a GWAS using data from a community-based cohort study where 3,647 subjects aged 40-89 were recruited by the Korea National Institute of Health (KNIH). The community-based cohort consisted of subjects who did not suffer from any of 6 major diseases (hypertension, hyperlipidemia, diabetes, heart diseases, brain diseases, and cancers). Epidemiologic information includes 249 traits such as epidemiological surveys, physical examinations, and laboratory tests. A total of 3,647 participants, including 234 hyperuricemia cases (serum uric acid [SUA] level was 7 mg/dL or higher) and 3,413 controls, were genotyped by Illumina HumanOmni1-Quad BeadChip GWAS array at KNIH. In the multivariate regression analysis of clinical variables, significant variables associated with hyperuricemia were male gender (odds ratio [OR], 5.526; P = 3.2x10(-10)), old age (OR, 1.017; P = 0.040), high body mass index (BMI) (OR, 1.147; P = 5.4x10(-7)), current alcohol intake (OR, 2.413; P = 4.7x10(-7)), and high creatinine (OR, 1.647; P = 1.6x10(-13)). We identified a hyperuricemia susceptible loci (rs2054576 in ABCG2, OR, 1.883; P = 4.7x10(-8)) that passed a genome-wide significance threshold, adjusted by clinical variables (male, age, BMI, current alcohol, and creatinine). It was first identified that rs2054576 in ABCG2 is associated with hyperuricemia. Our results should be validated through replication studies among other Korean subjects or various ethnic groups.
URI
https://jkms.org/DOIx.php?id=10.3346/jkms.2017.32.9.1451http://repository.hanyang.ac.kr/handle/20.500.11754/115669
ISSN
1011-8934; 1598-6357
DOI
10.3346/jkms.2017.32.9.1451
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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