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dc.contributor.author배상철-
dc.date.accessioned2019-11-30T18:15:02Z-
dc.date.available2019-11-30T18:15:02Z-
dc.date.issued2017-09-
dc.identifier.citationJOURNAL OF KOREAN MEDICAL SCIENCE, v. 32, no. 9, page. 1451-1459en_US
dc.identifier.issn1011-8934-
dc.identifier.issn1598-6357-
dc.identifier.urihttps://jkms.org/DOIx.php?id=10.3346/jkms.2017.32.9.1451-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/115624-
dc.description.abstractThe purpose of the present study was to find novel loci associated with hyperuricemia using data from a genome-wide association study (GWAS) conducted on healthy Koreans. We conducted a GWAS using data from a community-based cohort study where 3,647 subjects aged 40-89 were recruited by the Korea National Institute of Health (KNIH). The community-based cohort consisted of subjects who did not suffer from any of 6 major diseases (hypertension, hyperlipidemia, diabetes, heart diseases, brain diseases, and cancers). Epidemiologic information includes 249 traits such as epidemiological surveys, physical examinations, and laboratory tests. A total of 3,647 participants, including 234 hyperuricemia cases (serum uric acid [SUA] level was 7 mg/dL or higher) and 3,413 controls, were genotyped by Illumina HumanOmni1-Quad BeadChip GWAS array at KNIH. In the multivariate regression analysis of clinical variables, significant variables associated with hyperuricemia were male gender (odds ratio [OR], 5.526; P = 3.2x10(-10)), old age (OR, 1.017; P = 0.040), high body mass index (BMI) (OR, 1.147; P = 5.4x10(-7)), current alcohol intake (OR, 2.413; P = 4.7x10(-7)), and high creatinine (OR, 1.647; P = 1.6x10(-13)). We identified a hyperuricemia susceptible loci (rs2054576 in ABCG2, OR, 1.883; P = 4.7x10(-8)) that passed a genome-wide significance threshold, adjusted by clinical variables (male, age, BMI, current alcohol, and creatinine). It was first identified that rs2054576 in ABCG2 is associated with hyperuricemia. Our results should be validated through replication studies among other Korean subjects or various ethnic groups.en_US
dc.description.sponsorshipThis study was supported by the research fund of Hanyang University (HY-201300000001467).en_US
dc.language.isoen_USen_US
dc.publisherKOREAN ACAD MEDICAL SCIENCESen_US
dc.subjectABCG2en_US
dc.subjectHyperuricemiaen_US
dc.subjectUric Aciden_US
dc.titleABCG2 Polymorphism Is Associated with Hyperuricemia in a Study of a Community-Based Korean Cohorten_US
dc.typeArticleen_US
dc.relation.no9-
dc.relation.volume32-
dc.identifier.doi10.3346/jkms.2017.32.9.1451-
dc.relation.page1451-1459-
dc.relation.journalJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.contributor.googleauthorSon, Chang-Nam-
dc.contributor.googleauthorBang, So-Young-
dc.contributor.googleauthorKim, Sang-Hyon-
dc.contributor.googleauthorSung, Yoon-Kyoung-
dc.contributor.googleauthorBae, Sang-Cheol-
dc.contributor.googleauthorJun, Jae-Bum-
dc.relation.code2017002851-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
dc.identifier.orcidhttps://orcid.org/0000-0003-4658-1093-


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