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In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking

Title
In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking
Author
채영규
Keywords
Alcohol; Teratogenic effects; Epigenetics; FASD; FAS; Histone modifications
Issue Date
2017-09
Publisher
IVYSPRING INT PUBL
Citation
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, v. 13, no. 9, page. 1100-1108
Abstract
Ethanol is well known for its teratogenic effects during fetal development. Maternal alcohol consumption allows the developing fetus to experience the detrimental effects of alcohol exposure. Alcohol-mediated teratogenic effects can vary based on the dosage and the length of exposure. The specific mechanism of action behind this teratogenic effect is still unknown. Previous reports demonstrated that alcohol participates in epigenetic alterations, especially histone modifications during fetal development. Additional research is necessary to understand the correlation between major epigenetic events and alcohol-mediated teratogenesis such as that observed in fetal alcohol spectrum disorder (FASD). Here, we attempted to collect all the available information concerning alcohol-mediated histone modifications during gestational fetal development. We hope that this review will aid researchers to further examine the issues associated with ethanol exposure.
URI
http://www.ijbs.com/v13p1100.htmhttp://repository.hanyang.ac.kr/handle/20.500.11754/115605
ISSN
1449-2288
DOI
10.7150/ijbs.21047
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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