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dc.contributor.authorKAUSHIKNEHA-
dc.date.accessioned2019-11-30T16:43:24Z-
dc.date.available2019-11-30T16:43:24Z-
dc.date.issued2017-09-
dc.identifier.citationONCOTARGET, v. 8, no. 44, page. 77794-77808en_US
dc.identifier.issn1949-2553-
dc.identifier.urihttp://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=20783&path[]=66196-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/115590-
dc.description.abstractThe lack of effective anti-metastatic drugs for the eradication of breast cancer stem cells within tumors, which are often resistant to chemotherapy and radiotherapy, creates a major obstacle during metastatic breast cancer therapy. Although D-ribo-phytosphingosine (PHS) is well known to activate protein kinase (MAPK)-mediated apoptosis, its possible role towards the metastasis signaling mechanisms underlying the epithelial-mesenchymal transition (EMT) remains largely unknown. In this report, we investigate the anti-metastatic potential of the natural sphingolipid PHS for the targeting of breast cancer cells as well as breast stem-like cells in vitro. We showed that PHS led to suppression of migratory potential, spheroid formation, CD44(high)/CD24(low) subpopulation as well as stem cell-and EMT-associated protein expression in basal type highly malignant breast cancer cell lines. In addition, PHS-based inhibition of EMT was attributable to the downregulation of the EGFR/JAK1/STAT3 signaling axis, as validated by immunoprecipitation assays and breast tumorigenesis mice models. This study demonstrate that PHS can target metastatic tumors with dual specificity (EMT and cancer stem-like cells) and therefore may be serve as a promising candidate for breast cancer treatments.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation (NRF) and Ministry of Science, ICT and Future Planning, Korean Government, through its National Nuclear Technology Program NRF-2015M2A2A7A01044998 and the Korea Institute of Radiological and Medical Sciences (1711045557/1711045538/1711045554/50531-2017).en_US
dc.language.isoen_USen_US
dc.publisherIMPACT JOURNALS LLCen_US
dc.subjectphytosphingosineen_US
dc.subjectepithelial-mesenchymal transitionen_US
dc.subjectcancer stem cellsen_US
dc.subjectepidermal growth factor receptoren_US
dc.titlePhytosphingosine exhibits an anti-epithelial–mesenchymal transition function by the inhibition of EGFR signaling in human breast cancer cellsen_US
dc.typeArticleen_US
dc.relation.no44-
dc.relation.volume8-
dc.identifier.doi10.18632/oncotarget.20783-
dc.relation.page77794-77808-
dc.relation.journalONCOTARGET-
dc.contributor.googleauthorKang, Hye-Min-
dc.contributor.googleauthorSon, Han-Sun-
dc.contributor.googleauthorCui, Yan-Hong-
dc.contributor.googleauthorYoun, BuHyun-
dc.contributor.googleauthorSon, Beomseok-
dc.contributor.googleauthorKaushik, Nagendra Kumar-
dc.contributor.googleauthorUddin, Nizam-
dc.contributor.googleauthorLee, Jae-Seong-
dc.contributor.googleauthorSong, Jie-Young-
dc.contributor.googleauthorKaushik, Neha-
dc.relation.code2017009424-
dc.sector.campusS-
dc.sector.daehakRESEARCH INSTITUTE[S]-
dc.sector.departmentTHE RESEARCH INSTITUTE FOR NATURAL SCIENCES-
dc.identifier.pidneha1987-


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