Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김용희 | - |
dc.date.accessioned | 2019-11-30T09:01:20Z | - |
dc.date.available | 2019-11-30T09:01:20Z | - |
dc.date.issued | 2017-09 | - |
dc.identifier.citation | BIOMATERIALS, v. 148, page. 81-89 | en_US |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0142961217306087?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/115485 | - |
dc.description.abstract | Obesity is an increasingly prevalent global health problem. Due to its close relations with metabolic diseases and cancer, new therapeutic approaches for treating obesity and obesity-induced metabolic diseases are required. Visceral white adipose tissue (WAT) has been closely associated with obesity induced inflammation and adipose tissue macrophages (ATMs) are responsible for obesity-induced inflammation by releasing inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6. TNF-alpha converting enzyme (TACE) is a transmembrane enzyme that induces the enzymatic cleavage and release of inflammatory cytokines. In this study, we developed a nonviral gene delivery system consisting of an oligopeptide (ATS-9R) that can selectively target visceral ATMs. In here we shows visceral adipose tissue-dominant inflammatory gene over-expressions in obese mouse and our strategy enabled the preferential delivery of therapeutic genes to visceral ATMs and successfully achieved ATM targeted gene silencing. Finally, ATS-9R-mediated TACE gene silencing in visceral ATMs alleviated visceral fat inflammation and improved type 2 diabetes by reducing whole body inflammation. (C) 2017 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This work was partially supported by grants from the National Research Foundation of Korea (2017M3A9F5029655, 2015R1A2A1A09003019), the Brain Korea 21 plus program (22A20130011095), and the Korean Health Technology R&D project through the Ministry of Health and Welfare (HI17C0888). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCI LTD | en_US |
dc.subject | Adipose tissue macrophage | en_US |
dc.subject | Visceral adipose tissue | en_US |
dc.subject | Anti-inflammatory gene delivery | en_US |
dc.subject | Targeted gene delivery | en_US |
dc.title | Visceral adipose tissue macrophage-targeted TACE silencing to treat obesity-induced type 2 diabetes | en_US |
dc.type | Article | en_US |
dc.relation.volume | 148 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2017.09.023 | - |
dc.relation.page | 81-89 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.contributor.googleauthor | Yong, Seok-Beom | - |
dc.contributor.googleauthor | Song, Yoonsung | - |
dc.contributor.googleauthor | Kim, Yong-Hee | - |
dc.relation.code | 2017001471 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | yongheekim | - |
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