24 3

Full metadata record

DC FieldValueLanguage
dc.contributor.authorKAUSHIKNEHA-
dc.date.accessioned2019-11-27T00:24:59Z-
dc.date.available2019-11-27T00:24:59Z-
dc.date.issued2017-07-
dc.identifier.citationONCOTARGET, v. 8, no. 36, page. 60188-60200en_US
dc.identifier.issn1949-2553-
dc.identifier.urihttp://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=19028&path[]=60998-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/114892-
dc.description.abstractThe tumorigenic potentials of residual cancer stem-like cells within tumors represent limitations of current cancer therapies. Here, the authors describe the effects of synthesized flexible, ligated, supramolecular self-assembled chair type tetranuclear ruthenium (II) metallacycles (2-5) on glioblastoma and glioma stem like cells. These self-assemblies were observed to be selectively toxic to glioma cells and CD133-positive glioma stem like cells population. Of the self-assembled compounds tested, metallacycle 4 more efficiently induced glioma stem like cells death within a brain cancer cell population and simultaneously inhibited the formation of free-floating gliospheres by reducing the sphere size. Detailed cell death studies revealed that treatment with metallacycle 4 reduced mitochondrial membrane potentials (an indicator of apoptosis) of glioma stem like cells. These results shows the elimination of cancer stem-like cells using an appropriate ligand binding adaptor offers a potential means of developing metal-based compounds for the treatment of chemo-resistant tumors.en_US
dc.description.sponsorshipThis work was supported by the Basic Science Research program through the National Research Foundation of Korea (2016R1A2B4007433 to K.W.C and 2014R1A1A2007828 to P.E.), and by the Priority Research Centers program (2009-0093818) through the NRF. We also acknowledge the financial assistance afforded by the Korean government (MSIP) (NRF-2010-0027963), (NRF-2016K1A4A3914113), (NRF-2015M2A2A7A01044998), (NRF-2016R1C1B2010851). This work is supported by research grant of Kwangwoon University in 2017.en_US
dc.language.isoen_USen_US
dc.publisherIMPACT JOURNALS LLCen_US
dc.subjectself-assemblyen_US
dc.subjectflexible liganden_US
dc.subjectarene-rutheniumen_US
dc.subjectmetallacycleen_US
dc.subjectsolid canceren_US
dc.titleFlexible ligated ruthenium(II) self-assemblies sensitizes glioma tumor initiating cells in vitroen_US
dc.typeArticleen_US
dc.identifier.doi10.18632/oncotarget.19028-
dc.identifier.doi10.18632/oncotarget.19028-
dc.relation.page60188-60200-
dc.relation.journalONCOTARGET-
dc.contributor.googleauthorElumalai, Palani-
dc.contributor.googleauthorKaushik, Neha-
dc.contributor.googleauthorKim, Dong Hwan-
dc.contributor.googleauthorKim, Hyunuk-
dc.contributor.googleauthorLee, Su Jae-
dc.contributor.googleauthorChoi, Eun Ha-
dc.contributor.googleauthorChi, Ki-Whan-
dc.contributor.googleauthorKaushik, Nagendra Kumar-
dc.relation.code2017009424-
dc.sector.campusS-
dc.sector.daehakRESEARCH INSTITUTE[S]-
dc.sector.departmentTHE RESEARCH INSTITUTE FOR NATURAL SCIENCES-
dc.identifier.pidneha1987-


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE