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Flexible ligated ruthenium(II) self-assemblies sensitizes glioma tumor initiating cells in vitro

Title
Flexible ligated ruthenium(II) self-assemblies sensitizes glioma tumor initiating cells in vitro
Author
KAUSHIKNEHA
Keywords
self-assembly; flexible ligand; arene-ruthenium; metallacycle; solid cancer
Issue Date
2017-07
Publisher
IMPACT JOURNALS LLC
Citation
ONCOTARGET, v. 8, no. 36, page. 60188-60200
Abstract
The tumorigenic potentials of residual cancer stem-like cells within tumors represent limitations of current cancer therapies. Here, the authors describe the effects of synthesized flexible, ligated, supramolecular self-assembled chair type tetranuclear ruthenium (II) metallacycles (2-5) on glioblastoma and glioma stem like cells. These self-assemblies were observed to be selectively toxic to glioma cells and CD133-positive glioma stem like cells population. Of the self-assembled compounds tested, metallacycle 4 more efficiently induced glioma stem like cells death within a brain cancer cell population and simultaneously inhibited the formation of free-floating gliospheres by reducing the sphere size. Detailed cell death studies revealed that treatment with metallacycle 4 reduced mitochondrial membrane potentials (an indicator of apoptosis) of glioma stem like cells. These results shows the elimination of cancer stem-like cells using an appropriate ligand binding adaptor offers a potential means of developing metal-based compounds for the treatment of chemo-resistant tumors.
URI
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=19028&path[]=60998http://repository.hanyang.ac.kr/handle/20.500.11754/114892
ISSN
1949-2553
DOI
10.18632/oncotarget.1902810.18632/oncotarget.19028
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > THE RESEARCH INSTITUTE FOR NATURAL SCIENCES(자연과학연구소) > Articles
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