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Effect of synergistic interaction between abnormal adiposity-related metabolism and prediabetes on microalbuminuria in the general population

Title
Effect of synergistic interaction between abnormal adiposity-related metabolism and prediabetes on microalbuminuria in the general population
Author
이창화
Keywords
CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE; CARDIOMETABOLIC INDEX; OBESITY; RATIO; RISK; ASSOCIATION; INFLAMMATION; ALBUMINURIA; PROGRESSION
Issue Date
2017-06
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v. 12, no. 7, Article no. e0180924
Abstract
Central obesity and related metabolic components are important risks for microalbuminuria. To describe the effects of interactions between central obesity and related metabolic components on microalbuminuria, we conducted a nation-wide, population-based interaction analysis using cardio-metabolic index (CMI) as a candidate indicator of central obesity and related abnormal lipid metabolism. We recruited native Koreans aged 20 years or older with no medical illness. A total of 5398 participants were divided into quintiles according to CMI with sex as a covariate factor. Participants in the highest CMI quintile had elevated blood pressure (BP), increased glycemic exposure, poor lipid profile, and increased urine albumin-to-creatinine ratio compared to other lower quintiles. Multiple logistic regression models adjusted for age, sex, systolic BP, and diastolic BP showed that CMI had an independent association with increased glycemic exposure and increased urine albumin-to-creatinine ratio. Our interaction analysis revealed a significant interaction between the highest CMI quintile and prediabetes with an increased risk of microalbuminuria (adjusted RERI = 0.473, 95% CI = 0.464 +/- 0.482; adjusted AP = 0.276, 95% CI = 0.156 +/- 0.395; adjusted SI = 2.952, 95% CI = 1.234 +/- 4.670). Our findings suggest a significant association between central obesity-related abnormal lipid metabolism and prediabetes, and their interaction may exert a synergistic effect on renal vascular endothelial dysfunction even before the appearance of full-blown diabetes mellitus. To confirm these findings, large population-based prospective studies are needed.
URI
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180924http://repository.hanyang.ac.kr/handle/20.500.11754/114422
ISSN
1932-6203
DOI
10.1371/journal.pone.0180924
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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