19 0

Expression pattern of Smad4/GATA3 as a predictor of survival in invasive ductal carcinoma of the breast

Title
Expression pattern of Smad4/GATA3 as a predictor of survival in invasive ductal carcinoma of the breast
Author
민경환
Keywords
Smad4 protein; GATA3 protein; Prognosis; Breast cancer
Issue Date
2017-05
Publisher
KARGER
Citation
PATHOBIOLOGY, v. 84, no. 3, page. 130-138
Abstract
Background: Smad4 and GATA3 proteins are known prognostic markers in various cancers. Smad4 is a mediator linked to both tumour suppression and progression. GATA3 is a regulator of development and morphogenesis of the mammary gland. We assessed and compared the predictive performance of Smad4 and GATA3 for clinical outcomes in patients with breast cancer. Methods: The combined expression pattern based on Smad4+/- and GATA3+/- was evaluated by immunostaining using breast cancer tissue microarray, and the relationships between protein expression and clinicopathological variables were analysed. Results: Smad4 expression was only associated with an ill-defined tumour border, whereas GATA3 was associated with several good prognostic factors. On analysis of combined markers, there was a significant difference in the expression of fascin (an important factor for cancer invasiveness) between the Smad4+/GATA3- and Smad4-/GATA3+ groups. Smad4+/GATA3- was correlated with worse clinicopathological parameters, relapse-free survival (RFS), and overall survival (OS), compared to Smad4-/GATA3+. Conclusion: Combined markers of Smad4/GATA3 showed a superior performance compared to single markers for predicting RFS and OS in patients with breast cancer. (C) 2017 S. Karger AG, Basel
URI
https://www.karger.com/Article/FullText/449428http://repository.hanyang.ac.kr/handle/20.500.11754/114201
ISSN
1015-2008; 1423-0291
DOI
10.1159/000449428
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE