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Cytokeratin 17 Expression is Associated With Poor Prognosis in Gallbladder Adenocarcinoma

Title
Cytokeratin 17 Expression is Associated With Poor Prognosis in Gallbladder Adenocarcinoma
Author
민경환
Keywords
gallbladder; adenocarcinoma; cytokeratin 17; prognosis
Issue Date
2017-05
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v. 25, no. 5, page. 346-350
Abstract
Cytokeratin 17 (CK17), a basal/myoepithelial cell keratin, is a poor prognostic marker for cancers of organs such as the stomach, ovary, and breast as well as a useful diagnostic marker for pancreatobiliary adenocarcinoma. However, its expression pattern and prognostic significance have not been studied in gallbladder adenocarcinoma. We constructed a tissue microarray from samples from 82 consecutive patients with gallbladder adenocarcinoma treated by cholecystectomy at the Kangbuk Samsung Hospital from 2000 to 2011. CK17 expression was examined by immunohistochemistry and correlated with clinicopathologic prognostic factors. CK17 stained the cytoplasm of tumor cells and immunohistochemical interpretation was possible in 77 cases. Among these, 41 (53.2%) were considered positive using a 5% cutoff determined by a receiver operating characteristic curve (area under the curve = 0.656, P = 0.021). CK17 expression was associated with poor tumor differentiation (P < 0.001), high pT stage (P < 0.001), presence of distant metastasis (P = 0.036), and low disease-specific survival rate (P < 0.001). These results indicate that CK17 can be used as a marker for poor prognosis for gallbladder adenocarcinoma.
URI
https://insights.ovid.com/crossref?an=00129039-201705000-00009http://repository.hanyang.ac.kr/handle/20.500.11754/114200
ISSN
1541-2016; 1533-4058
DOI
10.1097/PAI.0000000000000307
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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