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Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells

Title
Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells
Author
서용준
Keywords
extracellular matrix remodeling; mesenchymal stem-like cells; hyaluronic acid; hyaluronic acid synthase-2; C5a
Issue Date
2017-03
Publisher
IMPACT JOURNALS LLC
Citation
ONCOTARGET, v. 8, no. 1, page. 1438-1448
Abstract
Hyaluronic acid (HA) is abundant in tumor microenvironment and closely associated with invasiveness of glioblastoma (GM) cells. However, the cellular mechanism underlying HA-rich microenvironment in GBM remains unexplored. Here, we show that tumor-associated mesenchymal stem-like cells (tMSLCs) contribute to abundance of hyaluronic acid (HA) in tumor microenvironment through HA synthase-2 (HAS2) induction, and thereby enhances invasiveness of GBM cells. In an autocrine manner, C5a secreted by tMSLCs activated ERK MAPK for HAS2 induction in tMSLCs. Importantly, HA acted as a signaling ligand of its cognate receptor RHAMM for intracellular signaling activation underlying invasiveness of GBM cells. Taken together, our study suggests that tMSLCs contribute to HA-rich proinvasive ECM microenvironment in GBM.
URI
http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=13638&path[]=43320http://repository.hanyang.ac.kr/handle/20.500.11754/113435
ISSN
1949-2553
DOI
10.18632/oncotarget.13638
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > THE RESEARCH INSTITUTE FOR NATURAL SCIENCES(자연과학연구소) > Articles
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