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dc.contributor.author신인철-
dc.date.accessioned2019-11-22T00:59:55Z-
dc.date.available2019-11-22T00:59:55Z-
dc.date.issued2017-03-
dc.identifier.citationBMB REPORTS, v. 50, no. 3, page. 132-137en_US
dc.identifier.issn1976-6696-
dc.identifier.issn1976-670X-
dc.identifier.urihttp://koreascience.or.kr/article/JAKO201713647761695.page-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/113391-
dc.description.abstractElevated glucose levels in cancer cells can be attributed to increased levels of glucose transporter (GLUT) proteins. Glut1 expression is increased in human malignant cells. To investigate alternative roles of Glut1 in breast cancer, we silenced Glut1 in triple-negative breast-cancer cell lines using a short hairpin RNA (shRNA) system. Glut1 silencing was verified by Western blotting and qRT-PCR. Knockdown of Glut1 resulted in decreased cell proliferation, glucose uptake, migration, and invasion through modulation of the EGFR/MAPK signaling pathway and integrin. beta 1/Src/FAK signaling pathways. These results suggest that Glut1 not only plays a role as a glucose transporter, but also acts as a regulator of signaling cascades in the tumorigenesis of breast cancer.en_US
dc.description.sponsorshipThis work was supported by an NRF grant (2016R1A2B4 011196) from the Korean Research Foundation.en_US
dc.language.isoen_USen_US
dc.publisherKOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGYen_US
dc.subjectBreast cancer cellen_US
dc.subjectEGFRen_US
dc.subjectGluten_US
dc.subjectIntegrin beta 1en_US
dc.subjectTriple-negative breast canceren_US
dc.titleGlut1 promotes cell proliferation, migration and invasion by regulating epidermal growth factor receptor and integrin signaling in triple-negative breast cancer cellsen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume50-
dc.identifier.doi10.5483/BMBRep.2017.50.3.189-
dc.relation.page132-137-
dc.relation.journalBMB REPORTS-
dc.contributor.googleauthorOh, Sunhwa-
dc.contributor.googleauthorKim, Hyungjoo-
dc.contributor.googleauthorNam, KeeSoo-
dc.contributor.googleauthorShin, Incheol-
dc.relation.code2017010823-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidincheol-


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