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Analysis of temporal firing patterns of primary afferent C-fibers for different sensations in mice

Title
Analysis of temporal firing patterns of primary afferent C-fibers for different sensations in mice
Author
김인영
Keywords
Neural prostheses; Spike pattern analysis; Primary afferent C-fibers
Issue Date
2017-03
Publisher
KOREAN SOC PRECISION ENG
Citation
INTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING, v. 18, no. 5, page. 739-745
Abstract
Some people with amputated limbs can benefit from neural prosthetics to restore tactile sensation through electrical stimulation of the afferent nerve. The temporal spike train pattern generated in healthy subject's nerve by various types of somatosensation could provide key information to closely mimic natural sensations using electrical stimulation. However, the temporal firing patterns of peripheral sensory fibers have not been well understood yet. To interpret somatosensory spike trains, we performed ex vivo singlefiber recordings from the saphenous nerve in isolated skin-nerve preparations from mice. Some mechanically sensitive primary afferent C-fibers could also be activated by hot, cold, and itching stimuli, and we observed stimulus-specific firing patterns. These temporal patterns of the C-fibers for chemical stimuli were analyzed using a computational model based on quadruplets of spikes, which we classified into three groups of responses, i.e., capsaicin (hot), allyl-isothiocyanate (cold), and alpha-methyl-serotonin (itching). Each group of responses to the chemical stimuli was different from that evoked by mechanical stimuli. Therefore, these findings indicate that nontactile somatosensation can be decoded and used as input to a computerized system. Our quadruplet approach to the temporal patterns of spike trains contributes valuable insight to the identification of temporal profiles of other biological conditions.
URI
https://link.springer.com/article/10.1007%2Fs12541-017-0088-2http://repository.hanyang.ac.kr/handle/20.500.11754/113273
ISSN
2234-7593; 2005-4602
DOI
10.1007/s12541-017-0088-2
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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