Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 성일훈 | - |
dc.date.accessioned | 2019-11-21T07:06:49Z | - |
dc.date.available | 2019-11-21T07:06:49Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.citation | WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE, v. 29, no. 3, page. 65-70 | en_US |
dc.identifier.issn | 1044-7946 | - |
dc.identifier.issn | 1943-2704 | - |
dc.identifier.uri | https://europepmc.org/abstract/med/28054921 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/113257 | - |
dc.description.abstract | Background. Although air pollution containing fine dust particles is gaining attention worldwide, little is known about the effects of such pollutants on diabetic wounds. Air pollutants from diesel exhaust particles (DEPs) cause inflammation, resulting in an increased expression of pro-inflammatory cytokines and chemokines, which attract monocytes and T cells to the sites of inflammation. The authors evaluated the effects of air pollutants on diabetic wounds. Materials and Methods. Fibroblast cells were derived from streptozotocin-induced diabetic rats. Cell Counting Kit-8 assays were used to determine cell viability. The expression of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6) was evaluated by reverse transcription polymerase chain reaction and western blot analysis. Results. The proliferation of DEP-treated fibroblasts decreased with time. The messenger ribonucleic acid expression of TNF-alpha and COX 2 in DEP-treated fibroblasts increased in both normal and diabetic fibroblasts, while IL-6 expression remained unchanged. The protein expression of TNF-alpha, COX-2, and IL-6 in DEP-treated fibroblasts increased compared to samples not exposed to DEP. Conclusions. Diesel exhaust particles regulate the expression of pro-inflammatory cytokines such as IL-6, TNF-alpha, and COX-2, which may impede diabetic healing in vitro. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Science, ICT and Future Planning (2014R1A1A1003181). The study was also partially supported by the Soonchunhyang University Research Fund. The authors disclose no financial or other conflicts of interest. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | H M P COMMUNICATIONS | en_US |
dc.subject | diabetic ulcers | en_US |
dc.subject | tissue repair | en_US |
dc.subject | diabetic foot | en_US |
dc.subject | diesel exhaust particles | en_US |
dc.subject | wound | en_US |
dc.subject | diabetes | en_US |
dc.title | Evaluation of the Effects of Air Pollutants on Diabetic Wounds | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 29 | - |
dc.relation.page | 65-70 | - |
dc.relation.journal | WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE | - |
dc.contributor.googleauthor | Choi, Young Suk | - |
dc.contributor.googleauthor | Sung, Il-Hoon | - |
dc.contributor.googleauthor | Lim, Ji Yun | - |
dc.contributor.googleauthor | Kyun, A. Hyun | - |
dc.contributor.googleauthor | Yeo, Eui Dong | - |
dc.contributor.googleauthor | Lee, Sun Geun | - |
dc.contributor.googleauthor | Lee, Young Koo | - |
dc.relation.code | 2017011798 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sungih | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.