Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2019-11-21T05:44:08Z | - |
dc.date.available | 2019-11-21T05:44:08Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.citation | Archives of Craniofacial Surgery, v. 18, no. 1, page. 9-15 | en_US |
dc.identifier.issn | 2287-1152 | - |
dc.identifier.issn | 2287-5603 | - |
dc.identifier.uri | https://e-acfs.org/journal/view.php?doi=10.7181/acfs.2017.18.1.9 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/113182 | - |
dc.description.abstract | Background: Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model. Methods: Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared. Results: Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group. Conclusion: Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated. | en_US |
dc.description.sponsorship | This work was supported by a faculty research grant of Yonsei University Collegeof Medicine (6-2012-0037, Dr, IS. Yun), grants from the Ministry of KnowledgeEconomy (10030051, Dr. C-O. Yun), the National Research Foundation of Korea(2010-0029220, 2013K1A1A2A02050188, 2013M3A9D3045879, Dr. C-O. Yunand NRF-2015R1D1A1A01060361, Dr. IS. Yun), and Korea Food and DrugAdministration (KFDA-13172-356, Dr. C-O. Yun). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | 대한두개안면성형외과학회 | en_US |
dc.subject | Gene therapy | en_US |
dc.subject | Cicatrix | en_US |
dc.subject | Relaxin | en_US |
dc.subject | Adenovirus | en_US |
dc.title | Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 18 | - |
dc.identifier.doi | 10.7181/acfs.2017.18.1.9 | - |
dc.relation.page | 9-15 | - |
dc.relation.journal | Archives of Craniofacial Surgery | - |
dc.contributor.googleauthor | Jung Bok Ki | - |
dc.contributor.googleauthor | Lee Won Jai | - |
dc.contributor.googleauthor | Kang Eunhye | - |
dc.contributor.googleauthor | Ahn Hyo Min | - |
dc.contributor.googleauthor | Kim Yong Oock | - |
dc.contributor.googleauthor | Rah Dong Kyun | - |
dc.contributor.googleauthor | Yun Chae-Ok | - |
dc.contributor.googleauthor | Yun In Sik | - |
dc.relation.code | 2017019842 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | chaeok | - |
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