Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study
- Title
- Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study
- Author
- 윤채옥
- Keywords
- Gene therapy; Cicatrix; Relaxin; Adenovirus
- Issue Date
- 2017-03
- Publisher
- 대한두개안면성형외과학회
- Citation
- Archives of Craniofacial Surgery, v. 18, no. 1, page. 9-15
- Abstract
- Background: Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model. Methods: Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared. Results: Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group. Conclusion: Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.
- URI
- https://e-acfs.org/journal/view.php?doi=10.7181/acfs.2017.18.1.9https://repository.hanyang.ac.kr/handle/20.500.11754/113182
- ISSN
- 2287-1152; 2287-5603
- DOI
- 10.7181/acfs.2017.18.1.9
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
- Files in This Item:
- Effect of Relaxin Expressing Adenovirus on Scar Remodeling A Preliminary Study.pdfDownload
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