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Structurally Stable Attractive Nanoscale Emulsions with DipoleDipole Interaction- Driven Interdrop Percolation

Title
Structurally Stable Attractive Nanoscale Emulsions with DipoleDipole Interaction- Driven Interdrop Percolation
Author
이영복
Keywords
attractive nanoemulsions; block copolymers; drop-percolated emulsion; drug delivery; lecithin
Issue Date
2017-03
Publisher
WILEY-V C H VERLAG GMBH
Citation
CHEMISTRY-A EUROPEAN JOURNAL, v. 23, v. 18, page. 4292-4297
Abstract
This study introduces an extremely stable attractive nanoscale emulsion fluid, in which the amphiphilic block copolymer, poly(ethylene oxide)-block-poly(e-caprolactone) (PEO-b-PCL), is tightly packed with lecithin, thereby forming a mechanically robust thin-film at the oil-water interface. The molecular association of PEO-b-PCL with lecithin is critical for formation of a tighter and denser molecular assembly at the interface, which is systematically confirmed by T-2 relaxation and DSC analyses. Moreover, suspension rheology studies also reflect the interdroplet attractions over a wide volume fraction range of the dispersed oil phase; this results in a percolated network of stable drops that exhibit no signs of coalescence or phase separation. This unique rheological behavior is attributed to the dipolar interaction between the phosphorylcholine groups of lecithin and the methoxy end groups of PEO-b-PCL. Finally, the nanoemulsion system significantly enhances transdermal delivery efficiency due to its favorable attraction to the skin, as well as high diffusivity of the nanoscale emulsion drops.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201604722http://repository.hanyang.ac.kr/handle/20.500.11754/113094
ISSN
0947-6539; 1521-3765
DOI
10.1002/chem.201604722
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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