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Multiple roles of CTDK-I throughout the cell

Title
Multiple roles of CTDK-I throughout the cell
Author
안성훈
Keywords
CTDK-I; Ctk1; CDK12; Genome stability; Translation; rRNA synthesis
Issue Date
2019-07
Publisher
SPRINGER BASEL AG
Citation
CELLULAR AND MOLECULAR LIFE SCIENCES, v. 76, No. 14, Page. 2789-2797
Abstract
The heterotrimeric carboxy-terminal domain kinase I (CTDK-I) in yeast is a cyclin-dependent kinase complex that is evolutionally conserved throughout eukaryotes and phosphorylates the C-terminal domain of the largest subunit of RNA polymerase II (RNApII) on the second-position serine (Ser2) residue of YSPTSPS heptapeptide repeats. CTDK-I plays indispensable roles in transcription elongation and transcription-coupled processing, such as the 3-end processing of nascent mRNA transcripts. However, recent studies have revealed additional roles of CTDK-I beyond its primary effect on transcription by RNApII. Here, we describe recent advances in the regulation of genomic stability and rDNA integrity by CTDK-I and highlight the previously underappreciated cellular roles of CTDK-I in rRNA synthesis by RNA polymerase I and translational initiation and elongation. These multiple roles of CTDK-I throughout the cell expand our understanding of how this complex functions to coordinate diverse cellular processes through gene expression and how the human orthologue exerts its roles in diseased states such as tumorigenesis.
URI
https://link.springer.com/article/10.1007%2Fs00018-019-03118-0http://repository.hanyang.ac.kr/handle/20.500.11754/113071
ISSN
1420-682X; 1420-9071
DOI
10.1007/s00018-019-03118-0
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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