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Neurogenesis in stroke recovery

Title
Neurogenesis in stroke recovery
Author
고성호
Keywords
Stroke; Neurogenesis; Neural stem cells
Issue Date
2017-02
Publisher
SPRINGER
Citation
TRANSLATIONAL STROKE RESEARCH, v. 8, no. 1, page. 3-13
Abstract
Stroke, resulting from limited blood flow to the brain, is one of the most important causes of morbidity and mortality worldwide. Stroke is classified as ischemic, due to lack of blood flow, or hemorrhagic, due to bleeding. Because 87 % of strokes are classified as ischemic, this type will be the predominant focus of this review. Except for thrombolytic therapy, there is no established treatment to reduce the neurological deficits caused by ischemic stroke. Therefore, it is necessary to develop new therapeutic strategies designed to improve neurological functions after ischemic stroke. Recently, therapies to enhance neurogenesis after ischemic stroke have been investigated. However, these approaches have not led to successful clinical outcomes. This review addresses the pathophysiology of stroke, neurogenesis after stroke, and how to stimulate these processes based on the current literature. Finally, ongoing clinical trials to improve neurological functions after stroke by enhancing neurogenesis are discussed in this review.
URI
https://link.springer.com/article/10.1007%2Fs12975-016-0460-zhttp://repository.hanyang.ac.kr/handle/20.500.11754/112910
ISSN
1868-4483; 1868-601X
DOI
10.1007/s12975-016-0460-z
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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