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Tree-structured survival analysis of patients with Pseudomonas aeruginosa bacteremia: A multicenter observational cohort study

Title
Tree-structured survival analysis of patients with Pseudomonas aeruginosa bacteremia: A multicenter observational cohort study
Author
김지은
Keywords
Pseudomonas aeruginosa; Bacteremia; Mortality
Issue Date
2017-02
Publisher
ELSEVIER SCIENCE INC
Citation
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 87, no. 2, page. 180-187
Abstract
This study aimed to construct a prediction algorithm, which is readily applicable in the clinical setting, to determine the mortality rate for patients with P. aeruginosa bacteremia. A multicenter observational cohort study was performed retrospectively in seven university-affiliated hospitals in Korea from March 2012 to February 2015. In total, 264 adult patients with monomicrobial P. aeruginosa bacteremia were included in the analyses. Among the predictors independently associated with 30-day mortality in the Cox regression model, Pitt bacteremia score >2 and high-risk source of bacteremia were identified as critical nodes in the tree-structured survival analysis. Particularly, the empirical combination therapy was not associated with any survival benefit in the Cox regression model compared to the empirical monotherapy. This study suggests that determining the infection source and evaluating the clinical severity are critical to predict the clinical outcome in patients with P. aeruginosa bacteremia. (C) 2016 Elsevier Inc. All rights reserved.
URI
https://www.sciencedirect.com/science/article/abs/pii/S0732889316303327?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/112805
ISSN
0732-8893; 1879-0070
DOI
10.1016/j.diagmicrobio.2016.10.008
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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