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Diagnostic performance of tomosynthesis and breast ultrasonography in women with dense breasts: a prospective comparison study

Title
Diagnostic performance of tomosynthesis and breast ultrasonography in women with dense breasts: a prospective comparison study
Author
구혜령
Keywords
Breast neoplasm; Ultrasonography; Tomosynthesis; Diagnostic performance; Mammographic density
Issue Date
2017-02
Publisher
SPRINGER
Citation
BREAST CANCER RESEARCH AND TREATMENT, v. 162, no. 1, page. 85-94
Abstract
To compare the diagnostic performances of tomosynthesis and ultrasonography as adjunctives to digital mammography in women with dense breasts. A total of 778 women with dense breasts underwent digital mammography with tomosynthesis and ultrasonography for screening and diagnostic purposes. The findings of tomosynthesis and ultrasonography were evaluated independently. The primary endpoint was overall diagnostic accuracy determined by area under the receiver operating characteristic curve (AUC). Secondary endpoints included sensitivity, specificity, and predictive values. Of the 778 participants, 698 women (140 breast cancers) were included in the analysis. Based on the AUC findings, the non-inferiority of tomosynthesis to ultrasonography was established in the overall group as well as in all subgroups except for that comprising women with extremely dense breast composition. There were no significant differences in AUC between tomosynthesis and ultrasonography among asymptomatic participants and participants who underwent imaging for screening (0.912 vs. 0.934 [P = 0.403] and 0.987 vs. 0.950 [P = 0.270], respectively). Tomosynthesis exhibited lower sensitivity (91.4 vs. 96.4%; P = 0.039), and higher specificity (83.9 vs. 70.4%; P < 0.001) and positive predictive value (58.7 vs. 45.0%; P < 0.001) than ultrasonography. Tomosynthesis exhibits comparable performance to ultrasonography as an adjunct to mammography for diagnosis of breast cancer, except among women with extremely dense breasts.
URI
https://link.springer.com/article/10.1007%2Fs10549-017-4105-zhttps://repository.hanyang.ac.kr/handle/20.500.11754/112679
ISSN
0167-6806; 1573-7217
DOI
10.1007/s10549-017-4105-z
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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