19 0

Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

Title
Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice
Author
양철수
Keywords
DIET-INDUCED OBESITY; PPAR-ALPHA; ENERGY-EXPENDITURE; RECEPTOR AGONISTS; MICROBIAL ECOLOGY; IGA PRODUCTION; ER STRESS; B-CELLS; AUTOPHAGY; ACTIVATION
Issue Date
2017-01
Publisher
NATURE PUBLISHING GROUP
Citation
MUCOSAL IMMUNOLOGY, v. 10, no. 1, page. 104-116
Abstract
In humans, the composition of gut commensal bacteria is closely correlated with obesity. The bacteria modulate metabolites and influence host immunity. In this study, we attempted to determine whether there is a direct correlation between specific commensal bacteria and host metabolism. As mice aged, we found significantly reduced body weight and fat mass in Atg7(Delta CD11c) mice when compared with Atg7(f/f) mice. When mice shared commensal bacteria by cohousing or feces transfer experiments, body weight and fat mass were similar in both mouse groups. By pyrosequencing analysis, Bacteroides acidifaciens (BA) was significantly increased in feces of Atg7(Delta CD11c) mice compared with those of control Atg7(f/f) mice. Wild-type C57BL/6 (B6) mice fed with BA were significantly more likely to gain less weight and fat mass than mice fed with PBS. Of note, the expression level of peroxisome proliferator-activated receptor alpha (PPARa) was consistently increased in the adipose tissues of Atg7(Delta CD11c) mice, B6 mice transferred with fecal microbiota of Atg7(Delta CD11c) mice, and BA-fed B6 mice. Furthermore, B6 mice fed with BA showed elevated insulin levels in serum, accompanied by increased serum glucagon-like peptide-1 and decreased intestinal dipeptidyl peptidase-4. These finding suggest that BA may have potential for treatment of metabolic diseases such as diabetes and obesity.
URI
https://www.nature.com/articles/mi201642http://repository.hanyang.ac.kr/handle/20.500.11754/112463
ISSN
1933-0219
DOI
10.1038/mi.2016.42
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE