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Dendropanax morbifera ameliorates thioacetamide-induced hepatic fibrosis via TGF-b1/Smads pathways

Title
Dendropanax morbifera ameliorates thioacetamide-induced hepatic fibrosis via TGF-b1/Smads pathways
Author
김영미
Keywords
hepatic fibrosis; thioacetamide; TGF-β1; α-smooth muscle actin; Dendropanax morbifera
Issue Date
2019-02
Publisher
IVYSPRING INT PUBL
Citation
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, v. 15, No. 4, Page. 800-811
Abstract
Hepatic fibrosis, characterized by persistent deposition of extracellular matrix (ECM) proteins, occurs in most types of chronic liver disease. The prevention of liver damage using extract of Dendropanax morbifera has been widely studied, but its molecular mechanism on the therapeutic efficacy of hepatic fibrosis is unclear. The aim of this study was to assess whether aquatic extract (DM) of D. morbifera ameliorates thioacetamide (TAA)-induced hepatic fibrosis. Hepatic fibrosis was induced by an intraperitoneal (i.p.) injection (150 mg/kg, twice per week) of TAA for 6 weeks. DM (50 mg/kg/day) or silymarin (50 mg/kg/day) was administered daily for 6 weeks. DM markedly reduced serum AST, ALT, ALP, and r-GTP in TAA-treated rats. DM significantly ameliorated the total glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activity in TAA-treated rats. In particular, DM significantly reduced expression of α-SMA, type I collagen, vimentin, TGF-β1 and p-Smad2/3 in hepatic fibrosis rats. The protective effects of DM on progression of hepatic fibrosis were clearly shown by detecting 4-hydroxyproline concentration and histopathological examination in the liver. Therefore, our data suggest that DM dramatically prevented hepatic fibrosis by inhibiting oxidative stress and the TGF-β1/Smads signaling pathways.
URI
https://www.ijbs.com/v15p0800.htmhttp://repository.hanyang.ac.kr/handle/20.500.11754/112384
ISSN
1449-2288
DOI
10.7150/ijbs.30356
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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