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Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes

Title
Clinical characteristics of parkinsonism in frontotemporal dementia according to subtypes
Author
김승현
Keywords
Parkinsonism; Frontotemporal dementia; Primary progressive aphasia; Motor neuron disease
Issue Date
2017-01
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF THE NEUROLOGICAL SCIENCES, v. 372, page. 51-56
Abstract
Background: We investigated the prevalence of parkinsonism in frontotemporal dementia (FTD) subtypes and the cognitive and behavioral differences between FTD with and without parkinsonism in a well-structured, prospective cohort.Methods: One hundred and ninety-one FTD patients were enrolled and all patients underwent comprehensive neurological evaluations, neuropsychological tests, and the Unified Parkinson's Disease Rating Scale.Results: The prevalence of parkinsonism was 38.7% (74 patients), and included 33 (46.5%) behavioral variant FTD (bvFTD), 16 (24.2%) semantic dementia (SD), 19 (45.2%) progressive nonfluent aphasia (PNFA), and 6 (50%) FTD associated with motor neuron disease (FTD-MND). SD patients with parkinsonism had higher CDR sum of boxes scores (9.7 +/- 4.5 vs 62 +/- 4.5, p = 0.024), frontal behavioral inventory total score (33.7 +/- 20.5 vs 24.3 +/- 14.5, p = 0.045), and executive function score of frontal executive dysfunction, disinhibition, and apathy (28.9 +/- 13.7 vs 19.2 +/- 12.9, p = 0.021) than those without parkinsonism. Seoul Instrumental Activities of Daily Living score (bvFTD: 23.5 +/- 11.7 vs 17.3 +/- 11.3, p = 0.031, SD: 23.1 +/- 11.1 vs 11.3 +/- 9.3, p = 0.005) was higher for bvFTD and SD with parkinsonism than for those without parkinsonism.Conclusions: Parkinsonism is found to be more common in patients with bvFTD, PNFA, and FTD-MND patients than those with SD. Behavioral disturbances were more prominent in SD with parkinsonism than without. Additional studies are needed to determine the pathomechanism and optimal treatment of parkinsonism in different FTD subtypes. (C) 2016 Elsevier B.V. All rights reserved.
URI
https://www.jns-journal.com/article/S0022-510X(16)30736-5/fulltexthttps://repository.hanyang.ac.kr/handle/20.500.11754/112321
ISSN
0022-510X; 1878-5883
DOI
10.1016/j.jns.2016.11.033
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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