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dc.contributor.author배옥남-
dc.date.accessioned2019-11-18T06:21:06Z-
dc.date.available2019-11-18T06:21:06Z-
dc.date.issued2019-01-
dc.identifier.citationFrontiers in Cell and Developmental Biology, v. 6, Article no. UNSP 175en_US
dc.identifier.issn2296-634X-
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fcell.2018.00175/full-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/112169-
dc.description.abstractEvery year stroke claims more than 6 million lives worldwide. The majority of them are ischemic stroke. Small molecule-based therapeutics for ischemic stroke has attracted a lot of attention, but none has been shown to be clinically useful so far. Hypoxia-inducible factor-1 (HIF-1) plays a crucial role in the transcriptional adaptation of cells to hypoxia. Small molecule-based hypoxia-mimetic agents either stabilize HIF-1 alpha via HIF-prolyl hydroxylases (PHDs) inhibition or through other mechanisms. In both the cases, these agents have been shown to confer ischemic neuroprotection in vitro and in vivo. The agents which act via PHD inhibition are mainly classified into iron chelators, iron competitors, and 2 oxoglutarate (2OG) analogs. This review discusses HIF structure and key players in the HIF-1 degradation pathway as well as the genes, proteins and chemical molecules that are connected to HIF-1 and how they affect cell survival following ischemic injury. Furthermore, this review gives a summary of studies that used PHD inhibitors and other HIF-1 alpha stabilizers as hypoxia-mimetic agents for the treatment of ischemic injury.en_US
dc.description.sponsorshipAM is funded by MRC grant (reference no: MR/R005923/1).en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.subjecthypoxia-inducible factor-1en_US
dc.subjectischemic strokeen_US
dc.subjectneuroprotectionen_US
dc.subjectiron chelatorsen_US
dc.subjecthypoxia mimetic agenten_US
dc.titleHypoxia mimetic agents for ischemic strokeen_US
dc.typeArticleen_US
dc.relation.no175-
dc.relation.volume6-
dc.identifier.doi10.3389/fcell.2018.00175-
dc.relation.page1-12-
dc.relation.journalFrontiers in Cell and Developmental Biology-
dc.contributor.googleauthorDavis, Charles K.-
dc.contributor.googleauthorJain, Saurabh A.-
dc.contributor.googleauthorBae, Ok-Nam-
dc.contributor.googleauthorMajid, Arshad-
dc.contributor.googleauthorRajanikant, G. K.-
dc.relation.code2019016878-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidonbae-


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