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생후 6일째(P6) 쥐와 성체 쥐의 해마체에서 시냅스의 발달과 프로테아좀 활성에 관한 연구

Title
생후 6일째(P6) 쥐와 성체 쥐의 해마체에서 시냅스의 발달과 프로테아좀 활성에 관한 연구
Other Titles
Comparison of synaptic development and proteasome activity in P6 and adult rat hippocampus
Author
서혜명
Issue Date
2005-12
Publisher
한양대학교 이학기술연구소
Citation
이학기술연구지, v. 8, Page. 69-74
Abstract
Dysfunction of ubiquitin-proteasome system (UPS) has been proposed or implicated in the pathological processing of several neurodegenerative diseases and abnormalities in development. To address the differences of UPS in the synaptic development, we determined the proteasome activities in the hippocampus of postnatal day 6 (P6) and adult rats. Using ELISA and western blot, we found that the hippocampal NGF expression level is 1.3 times higher and synaptophysin level is significantly lower in P6 compared to adults. Interestingly, P6 rats in development showed 3-5 times higher hippocampal proteasome activities compared to adults. These results suggest that ubiquitin-proteasome activities are potentially related to synaptic development.
URI
https://www.earticle.net/Article/A106224http://repository.hanyang.ac.kr/handle/20.500.11754/111935
ISSN
2005-9051
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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