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Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex

Title
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex
Author
안성훈
Issue Date
2005-11
Publisher
CELL PRESS
Citation
CELL, v. 123, No. 4, Page. 593-605
Abstract
The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two distinct complexes. The smaller complex, Rpd3C(S), shares Sin3 and Ume1 with Rpd3C(L) but contains the unique subunits Rco1 and Eaf3. Rpd3C(S) mutants exhibit phenotypes remarkably similar to those of Set2, a histone methyltransferase associated with elongating RNA polymerase II. Chromatin immunoprecipitation and biochemical experiments indicate that the chromodomain of Eaf3 recruits Rpd3C(S) to nucleosomes methylated by Set2 on histone H3 lysine 36, leading to deacetylation of transcribed regions. This pathway apparently acts to negatively regulate transcription because deleting the genes for Set2 or Rpd3C(S) bypasses the requirement for the positive elongation factor Bur1/ Bur2.
URI
https://www.sciencedirect.com/science/article/pii/S0092867405011591http://repository.hanyang.ac.kr/handle/20.500.11754/111841
ISSN
0092-8674; 1097-4172
DOI
10.1016/j.cell.2005.10.025
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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