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Efficacy and Safety of Switching to Teneligliptin in Patients with Type 2 Diabetes Inadequately Controlled with Dipeptidyl Peptidase-4 Inhibitors: A 12-Week Interim Report

Title
Efficacy and Safety of Switching to Teneligliptin in Patients with Type 2 Diabetes Inadequately Controlled with Dipeptidyl Peptidase-4 Inhibitors: A 12-Week Interim Report
Author
이창범
Keywords
Diabetes mellitus; Type 2; Dipeptidyl-peptidase IV inhibitors; Teneligliptin
Issue Date
2019-08
Publisher
SPRINGER HEIDELBERG
Citation
DIABETES THERAPY, v. 10, NO 4, Page. 1271-1282
Abstract
Introduction Teneligliptin, an antidiabetic agent classified as a class III dipeptidyl peptidase-4 (DPP-4) inhibitor, has a unique structural feature that provides strong binding to DPP-4 enzymes. We investigated the efficacy and safety of switching patients with type 2 diabetes mellitus (T2DM) who had inadequate glycemic control on a stable dose of other DPP-4 inhibitors to teneligliptin.Methods Patients with T2DM whose glycosylated hemoglobin (HbA1c) levels were >= 7% despite taking DPP-4 inhibitors other than teneligliptin, with or without other hypoglycemic agents, for at least 3months were enrolled. The DPP-4 inhibitors taken before participating in the study were switched to 20mg qd teneligliptin, and this was to be maintained for 52weeks. The primary end point was the change in HbA1c levels after 12weeks. Metabolic parameters including fasting plasma glucose (FPG) and blood lipids were assessed also. To assess safety, adverse and hypoglycemic events were monitored. The data from baseline to week 12 were used for analysis in this interim report.Results The mean change in HbA1c levels from baseline to week 12 was - 0.44%. At week 12, the percentage of patients achieving HbA1c<7.0% was 31.6% and that of achieving HbA1c<6.5% was 11.4%, respectively. In 41.2% of patients, the HbA1c levels decreased by at least 0.5% at 12weeks. The mean change in FPG levels from baseline to week 12 was - 11.5mg/dl. No severe hypoglycemia was reported. Conclusion After switching to teneligliptin, HbA1c levels decreased significantly in patients with T2DM inadequately controlled with other DPP-4 inhibitors.Trial RegistrationClinicalTrials.gov, NCT03793023.FundingHandok Inc.
URI
https://link.springer.com/article/10.1007%2Fs13300-019-0628-0http://repository.hanyang.ac.kr/handle/20.500.11754/111807
ISSN
1869-6953; 1869-6961
DOI
10.1007/s13300-019-0628-0
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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