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Titanium dioxide nanoparticles induce apoptosis by interfering with EGFR signaling in human breast cancer cells.

Title
Titanium dioxide nanoparticles induce apoptosis by interfering with EGFR signaling in human breast cancer cells.
Author
신인철
Keywords
Titanium dioxide nanoparticles; Cytotoxicity; EGFR; Ligand-receptor interaction
Issue Date
2019-08
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
ENVIRONMENTAL RESEARCH, v. 175, Page. 117-123
Abstract
Titanium dioxide nanoparticles, due to their smaller size and increased surface area comparted to the bulk form, are known to be bioreactive and have unexpected toxicological outcomes. Previous studies have shown that nanoscale titanium dioxide induces reactive oxygen species (ROS)-mediated cytotoxicity and genotoxicity. Although many reports have discussed the ROS-mediated cytotoxic effects of titanium dioxide nanoparticles (TiO2-NPs), their effects on the receptor-ligand association are unknown. In this study, the possibility that TiO2-NPs can interfere with the receptor-ligand binding was assessed by monitoring alterations in the phosphorylation status of proteins downstream of the epidermal growth factor receptor (EGFR) signaling cascade. TiO2-NPs blocked ligand-induced EGFR autophosphorylation, leading to the deactivation of EGFR downstream effectors such as Akt and extracellular signal-regulated kinase signaling, inducing cell death.
URI
https://www.sciencedirect.com/science/article/pii/S0013935119302531?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/111687
ISSN
0013-9351; 1096-0953
DOI
10.1016/j.envres.2019.05.001
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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