Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2019-10-24T07:56:20Z | - |
dc.date.available | 2019-10-24T07:56:20Z | - |
dc.date.issued | 2005-09 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 301, No. 1-2, Page. 54-61 | en_US |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.issn | 1873-3476 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0378517305003340 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/111481 | - |
dc.description.abstract | To develop a poloxamer-based solid suppository with poloxamer mixtures, the melting point of various formulations composed of poloxamer 124 (P 124) and poloxamer 188 (P 188) were investigated. The dissolution and pharmacokinetic study of diclofenac sodium delivered by the poloxamer-based suppository were performed. Furthermore, the identification test in the rectum and morphology test of rectal tissues were carried out after its rectal administration in rats. The poloxamer mixtures composed of P 124 and P 188 were homogeneous phases. Very small amounts of P 188 affected the melting point of poloxamer mixtures. In particular, the poloxamer mixture [P 124[P 188 (97/3%)] with the melting point of about 32 degrees C was a solid form at room temperature and instantly melted at physiological temperature. Very small amounts of P 188 hardly affected the dissolution rates of diclofenac sodium from the suppository. Dissolution mechanism analysis showed the dissolution of diclofenac sodium was proportional to the time. The poloxamer-based suppository gave significantly higher initial plasma concentrations and faster T x of diclofenac sodium than did conventional PEG-based suppository, indicating that the drug from poloxamer-based suppository could be absorbed faster than that from PEG-based one in rats. It retained in the rectum for at least 4 h and could not irritate or damage the rectal tissues of rats. Thus, the poloxamer-based solid suppository with P 124 and P 188 was a mucoadhesive, safe and effective rectal dosage form for diclofenac sodium. (C) 2005 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This research was supported by grant No. RTI04-01-04 from the Regional Technology Innovation Program of the Ministry of Commerce, Industry and Energy (MOCIE) and by a grant from the Ministry of Science and Technology, South Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | diclofenac sodium | en_US |
dc.subject | poloxamer 124 | en_US |
dc.subject | poloxamer 188 | en_US |
dc.subject | mucoadhesive | en_US |
dc.subject | poloxamer-based solid suppository | en_US |
dc.subject | pharmacokinetics | en_US |
dc.title | Physicochemical characterization and in vivo evaluation of poloxamer-based solid suppository containing diclofenac sodium in rats | en_US |
dc.type | Article | en_US |
dc.relation.volume | 301 | - |
dc.identifier.doi | 10.1016/j.ijpharm.2005.05.037 | - |
dc.relation.page | 54-61 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.contributor.googleauthor | Yong, Chul Soon | - |
dc.contributor.googleauthor | Oh, Yu-Kyoung | - |
dc.contributor.googleauthor | Kim, Yong-Il | - |
dc.contributor.googleauthor | Kim, Jong Oh | - |
dc.contributor.googleauthor | Yoo, Bong-Kyu | - |
dc.contributor.googleauthor | Rhee, Jong-Dal | - |
dc.contributor.googleauthor | Lee, Kang Choon | - |
dc.contributor.googleauthor | Kim, Dae-Duk | - |
dc.contributor.googleauthor | Park, Young-Joon | - |
dc.contributor.googleauthor | Kim, Chong-Kook | - |
dc.contributor.googleauthor | Choi, Han-Gon | - |
dc.relation.code | 2009204294 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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