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dc.contributor.author백승삼-
dc.date.accessioned2019-10-18T01:26:33Z-
dc.date.available2019-10-18T01:26:33Z-
dc.date.issued2019-02-
dc.identifier.citationCANCER LETTERS, v. 454, Page. 44-52en_US
dc.identifier.issn0304-3835-
dc.identifier.issn1872-7980-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0304383519302320?via%3Dihub-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/111214-
dc.description.abstractHepatocellular carcinoma (HCC) is currently the third leading cause of cancer death worldwide. To study how mycoplasma infection affects HCC progression, we investigated the characteristics of mycoplasma-infected tumor tissues and circulating tumor cells (CTCs) in HCC patients. The mycoplasmal membrane protein p37 showed significant correlations with higher histologic stages and vascular invasion and predicted poor disease-free survival of HCC patients. p37-positive CTCs were detected in 42 out of 47 HCC patients (89%). p37-positive circulating cells were also detected in 4 out of 10 healthy donors (40%), and all were epithelial cell adhesion molecule (EpCAM)-positive. In HCC patients, most of p37-negative CTCs (95%) showed intermediate phenotype with neither EpCAM nor vimentin expression, but p37 -positive CTCs were EpCAM-positive (44%), vimentin-positive (32%), and both negative (24%), suggesting that EpCAM-positive CTCs are enriched with mycoplasma infection. Mycoplasma infection promoted migratory capacity of HCC cells with increased expression of EpCAM. Immunoprecipitation analysis revealed that p37 associates with EpCAM. The results suggest that mycoplasma infection promotes tumor progression in HCC patients via interaction of the mycoplasmal p37 and EpCAM.en_US
dc.description.sponsorshipThis study was supported in part by the National Research Foundation (NRF) of Korea (2016R1A2B4008610 and 2018M2A2B3A02072345). This work was also in part supported by grants from the Medical Research Center (2017R1A5A2015395), funded by the NRF of Korea.en_US
dc.language.isoenen_US
dc.publisherELSEVIER IRELAND LTDen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectMycoplasmal p37 proteinen_US
dc.subjectCirculating tumor cellen_US
dc.subjectEpCAMen_US
dc.subjectInvasion and migrationen_US
dc.titleMycoplasma infection promotes tumor progression via interaction of the mycoplasmal protein p37 and epithelial cell adhesion molecule in hepatocellular carcinomaen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.canlet.2019.04.007-
dc.relation.page44-52-
dc.relation.journalCANCER LETTERS-
dc.contributor.googleauthorKim, Min Kyu-
dc.contributor.googleauthorShin, Su-Jin-
dc.contributor.googleauthorLee, Hyun Min-
dc.contributor.googleauthorChoi, Hong Seo-
dc.contributor.googleauthorJeong, Jaemin-
dc.contributor.googleauthorKim, Hyunsung-
dc.contributor.googleauthorPaik, Seung Sam-
dc.contributor.googleauthorKim, Mimi-
dc.contributor.googleauthorChoi, Dongho-
dc.contributor.googleauthorRyu, Chun Jeih-
dc.relation.code2019003359-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidsspaik-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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